Effect of Kaempferia parviflora Wall. ex. Baker on
sexual activity of male rats and its toxicity

Sudwan, Paiwan; Saenphet, Kanokporn; Saenphet, Supap; Suwansirikul, Songkiet

Abstract

Kaempferia parviflora Wall. Ex. Baker (Krachaidum) has long been used among Thai men for sexual enhancement. The aim of this study was to determine the effect of K. parviflora ethanolic extract on the sexual behavior of male rats and its toxicity. The experiment was divided into three groups of rats given K. parviflora extract at doses of 60, 120, and 240 mg/kg BW for 60 days, whilst a control group received distilled water at 1 ml/day per oral. The results showed that all groups of male rats had significantly higher courtship behavior during the first 10-minute period of observation than in the 2nd and 3rd 10-minute periods, except those receiving the highest dose of K. parviflora. They revealed the same amount of courtship behavior throughout a whole 30-minute period, which was significantly lower than the control group. There was no significant difference between treated and control groups in other sexual behaviors; mount frequency (MF), intromission frequency (IF), mount latency (ML), or intromission latency (IL). Toxicological study revealed no significant difference of hemoglobin, WBC or differential cell count. All dosages had no effect on kidney and liver function, according to the normal values of blood urea nitrogen (BUN), creatinine (Crea), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Nevertheless, the histopathological study showed a morphological change in the liver. It was concluded that K. parviflora extract at 240 mg/kg BW reduced the time in the first 10 mintues of rat courtship behavior and the use of high and chronic doses of K. parviflora in humans should be considered inadvisable.

References:

Chaturapanich, G.; Chaiyakul, S.; Verawatnapakul, V.; Yimlamai, T.; Pholpramool, C.(2012), Enhancement of aphrodisiac activity in male rats by ethanol extract of Kaempferia parviflora and exercise training, Andrologia, Vol 44 (Suppl 1), Pages 323-328

Deema P. (2007), Effect of Kaempferia parviflora and Endurance Training on Lactate Threshold in Humans Phitsanulok, Thailand: Naresuan University

Matsushita, M. ; Yoneshiro, T.; Aita, S.; Kamiya, T.; Kusaba, N.; Yamaguchi, K.; Takagaki, K.; Kameya, T.; Sugie, H.; Saito, M. (2015), Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue Journal of Nutritional Science and Vitaminology, Volume 61 (1), Pages 79-83, 10.3177/jnsv.61.79

Murata, K.; Deguchi, T. ; Fujita, T.; Matsuda, H. (2013), Improvement in blood fluidity by Kaempferia parviflora rhizome, Journal of Natural Medicines, Vol 67, Pages 719-724

Promthep, K.; Eungpinichpong, W.; Sripanidkulchai, B. (2015) Chatchawan U: effect of Kaempferia parviflora extract on physical fitness of soccer players: a randomized double-blind placebo-controlled trial Medical Science Monitor Basic Research, Volume 21, Pages 100-108, 10.12659/MSMBR.894301

Saokaew, Surasak; Wilairat, Preyanate; Raktanyakan, Paranya (2016), Clinical Effects of Krachaidum (Kaempferia parviflora): A Systematic Review, Journal of Evidence-Based Integrative Medicine, Evidence-Based Complementary and Alternative Medicine, Vol 22(3) Pages 413-428

Wattanapitayakul, S.K.; Chularojmontri, L.; Herunsalee, A.; Charuchongkolwongse, S.; Chansuvanich, N. (2008), Vasorelaxation and antispasmodic effects of Kaempferia parviflora ethanolic extract in isolated rat organ studies , Fitoterapia, Volume 79, Pages 214-216, 10.1016/j.fitote.2007.11.017

Yoshino, S.; Kim, M.; Awa, R.; Kuwahara, H.; Kano, Y.; Kawada, T. (2014), Kaempferia parviflora extract increases energy consumption through activation of BAT in mice Food Science & Nutrition, Volume 2 (6), Pages 634-637, 10.1002/fsn3.144


Available on Amazon in (please click):

https://www.amazon.com/dp/B0B5N46JPH - Black Ginger, 155 Vegetarian Capsules of 500 mg of Fermented Thai 1:60 Extract
Product details

https://www.amazon.com/dp/B0B5N6H6WK - Black Ginger, 110 Vegetarian Capsules of 500 mg of Fermented Thai 1:60 Extract
Product details

https://www.amazon.com.au/dp/B09VBPRKPG - Black Ginger (Kaempferia Parviflora) Thai Grade AA 1:60 Extract, 30 caps @ 500 mg
Product details

https://www.amazon.com/dp/B09SSXCFDC - Kaempferia Parviflora (Krachai Dum, Krachai Dam, Black Ginger) 30 x 500 mg, Thai Grade AA 1:60 Extract - Instock on Amazon
Product details

https://www.amazon.ca/dp/B09TVH4KHN - Late Harvest 30x500mg Black Ginger from Thailand 1:60 Extract in Canada
Product details

https://www.amazon.com/dp/B09RJQYHXN - Black Ginger (Kaempferia Parviflora), 155 x 500 mg Fermented Micronized Thai Grade AA 1:60 Extract - Incoming stock on Amazon
Product details

https://www.amazon.com/dp/B09R4PKKY2 - Black Ginger 60 caps @ 600 mg (Kaempferia Parviflora), Thai Grade A 1:60 Extract
Product details

https://www.amazon.com.au/dp/B09R6NWHKY - Black Ginger, 70 capsules of 600 mg, (Kaempferia Parviflora) Thai Grade A 1:60 Extract
Product details

https://www.amazon.ca/dp/B09WQ6KD5W - Black Ginger (Kaempferia Parviflora), 100x500mg - Instock on Amazon
Product details

https://www.amazon.com/dp/B09WPTPCVF - Black Ginger (Kaempferia Parviflora) 105 Caps @ 500 mg Fermented Micronized Grade AA Thai 1:60 Extract - Instock on Amazon
Product details

https://www.amazon.ca/dp/B09Y23SDV1 - Black Ginger (Kaempferia Parviflora), 110x500, Thai Fermented Grade AA 1:60 Extract - Instock on Amazon
Product details

https://www.amazon.com.au/dp/B09Y15TWZ3 - Black Ginger (Kaempferia Parviflora), 110 Capsules @ 500 mg
Product details